I’m not sure exactly what spadoodios tend to be
It is a portmanteau of “doodie” (poop) and “Spaghetti-os”.
The Spaghettio-s jingle moved “Uh oh, Spaghettios”
Uh Oh Spadoodios
The laugh is the fact that he had been making use of the range from a classic advertisements for
Cook Boy-ar-de Spagetti-os. In ther commercial a young child states “Oh Oh, spagetti-os. Stewie states a variation thereon range as he had been speaking about, doo dy, do do, or poop. Spadoodios