Two reactions between a Grignard reagent and a carbonyl compound
are given beneath. Draw the primary natural product for every response
and point out if H+ or H- is required to finish every response. (The
beginning materials constructions are supplied within the reply fields as a
start line in your drawings.) Two reactions between a Grignard reagent and a carbonyl compound are given beneath. Draw the primary natural product for every response and point out if H+ or H- is required to finish every response. (The beginning materials constructions are supplied within the reply fields as a place to begin in your drawings.)
Normal steering
Ideas and cause
This downside is predicated on the idea of response of Grignard reagent with carbonyl compounds.
Carbonyl compounds (aldehydes and ketones) are extraordinarily reactive in direction of the nucleophile on account of their extremely electrophilic nature. Carbonyl teams embrace a carbon which is hooked up to the oxygen atom which extremely electronegative as in comparison with the carbon and therefore attracts the shared pair of electrons which ends up in the technology of partial optimistic character on the carbonyl carbon.
Fundamentals
Grignard reagents on response with carbonyl compounds perform a nucleophilic addition response which on remedy with water provides a corresponding alcohol.
Step-by-step
Step 1 of two
(1)
The response of Grignard reagent with the ketone is given beneath:
The natural product of the response is
.
Butan-2-one reacts with methyl magnesium bromide in presence of to kind 2-methylbutan-2-ol.
Aldehydes react with Grignard reagents in presence of to kind secondary alcohols.
Step 2 of two
(2)
The response of Grignard reagent with the aldehyde is given beneath:
The natural product of the response is
.
Butyraldehyde reacts with ethyl magnesium bromide in presence of to kind hexan-3-ol.
Reply
The natural product of the response is
.
The natural product of the response is
.
Reply solely
The natural product of the response is
.
The natural product of the response is
.
1. CH3MgBr 2. H+ butan-2-one 2-methylbutan-2-ol
1. CH3CH MgBr Η 2. H+ butyraldehyde hexan-3-ol
and Ht
and Ht
and H
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